Wednesday, April 9, 2014

Fats are not the enemy

Allison Aubrey presented a case for adding some fat to our diets on  NPR's Morning Edition as few weeks back.

Fats have been the target of most of the popular dietary plans. They are looked upon as the enemy to any healthy lifestyle. But is that justifiable and right?

It is well documented that saturated fats can raise the LDL ( Low-density lipoprotein)in the blood, which is the so-called bad cholesterol. Whereas on the other end, plant-based fats such as those found in nuts and olive oil are actually beneficial to our heart health and can help reduce the risk of heart disease. Yet it seems the risks might be more then the benefits, leading most of us to minimize fats intake whenever trying to eat healthy.

Thus the task of  convincing most of us to bring some ats back into our diets is a tough one.
Here is an excerpts of what experts had to say to Allison Aubrey on the subject;

"Fat was really the villain," says , who is chairman of the department of nutrition at the Harvard School of Public Health. And, by default, people "had to load up on carbohydrates."
But, by the mid-1990s, Willett says, there were already signs that the high-carb, low-fat approach might not lead to fewer heart attacks and strokes. He had a long-term study underway that was aimed at evaluating the effects of diet and lifestyle on health.
"We were finding that if people seemed to replace saturated fat — the kind of fat found in cheese, eggs, meat, butter — with carbohydrate, there was no reduction in heart disease," Willett says.
Willett submitted his data to a top medical journal, but he says the editors would not publish his findings. His paper was turned down.
"There was a lot of resistance to anything that would question the low-fat guidelines," Willett says, especially the guidelines on saturated fat.
Willett's was eventually published by a British medical journal, the BMJ, in 1996.

But here's where it gets interesting: "We've learned that carbohydrates aren't neutral," explains , an epidemiologist at Harvard Medical School.
"[Carbs] were the base of the pyramid," says Mozaffarian. The message was "eat all carbohydrates you want."
Americans took this as a green light to eat more refined grains such as breads, processed snack foods and white pasta.
"But carbohydrates worsen glucose and insulin — they have negative effects on blood cholesterol levels," he says. The thinking that it's OK to swap saturated fats for these refined carbs "has not been useful advice."
He says it's clear that saturated fats can raise LDL cholesterol, the bad cholesterol. But that's only one risk factor for heart disease.
There's now evidence that — compared with carbs — saturated fat can raise HDL cholesterol (the good cholesterol) and lower trigylcerides in the blood, which are both countering effects to heart disease, he says.
"When you put all of this together," says Mozaffarian, what you see is that saturated fat has a relatively neutral effect compared with carbs. He says it's "not a beneficial effect but not a harmful effect. And I think that's what the recent studies show." He points to a of studies published in 2010.

He also points to a highly publicized that concludes there's no convincing evidence to support the dietary recommendations to limit saturated fat.

The in that paper have created quite a bit of controversy. For instance, the American Heart Association it stands by its recommendations to limit saturated fat.


Although these new points of view don't say 'Go ahead and load up on fats' they do make it clear that fats should not be excluded from our diets completely. Maybe moderation is a good way to go with all diets. 

 
References:
Rethinking Fat: The Case For Adding Some Into Your Diet (NPR)

 

Friday, April 4, 2014

No such thing as right-brained or left-brained

Remember all those quizzes meant to figure out whether you are left-brained or right-brained? Well, researchers have just declared them all useless since there is no such thing as left-brained or right-brained.
Although distinct skills have been attributed to whichever hemisphere is dominant for ages and seemed to make sense but sadly they have no scientific basis according to a two year research completed by neuroscientists at University of Utah. The study published in the Plos One Journal is based on a two years long study involving scanning the brains of more then a 1000 individuals between the ages of 7-29 while performing such simple tasks such as lying quietly or reading. These scans were used to measure these individuals' brain functional lateralization meaning the specific mental functions occurring on each side of the brain. For accuracy functional lateralization was measured for each pair of 7266 regions of the grey matter.
Analysis of the data collected as a result lead to the conclusion
" An individual brain is not “left-brained” or “right-brained” as a global property, but that asymmetric lateralization is a property of individual nodes or local subnetworks, and that different aspects of the left-dominant network and right-dominant network may show relatively greater or lesser lateralization within an individual. If a connection involving one of the left hubs is strongly left-lateralized in an individual, then other connections in the left-dominant network also involving this hub may also be more strongly left lateralized, but this did not translate to a significantly generalized lateralization of the left-dominant network or right-dominant network. Similarly, if a left-dominant network connection was strongly left lateralized, this had no significant effect on the degree of lateralization within connections in the right-dominant network, except for those connections where a left-lateralized connection included a hub that was overlapping or close to a homotopic right-lateralized hub."

(Read Complete Article)








References:


Monday, March 24, 2014

Lost sleep = Lost Brain Cells

Yes, you read right.
Insufficient sleep is not only detrimental for our physical health but a recent study says it also leads to brain cell death.

The study conducted at University of Pennsylvania School of Medicine was published in the latest issue of The Journal of Neuroscience. While studying lack of sleep in mice, the researchers noticed prolonged lack of sleep lead to 25% of certain brain cells dying. After further observation and research the team concluded that similar damage is most likely occurs in human too.

As explained in the abstract of the article, "Modern society enables a shortening of sleep times, yet long-term consequences of extended wakefulness on the brain are largely unknown. Essential for optimal alertness, locus ceruleus neurons (LCns) are metabolically active neurons that fire at increased rates across sustained wakefulness. We hypothesized that wakefulness is a metabolic stressor to LCns and that, with extended wakefulness, adaptive mitochondrial metabolic responses fail and injury ensues."

With prolonged sleep deprivation the processes that maintain a health metabolic homeostasis in the brain can not be sustained, hence may lead to significant irreversible injury.  Although much more research and work needs to be done to determine whether loss of sleep can lead to real brain damage.

In the end, for all of us who survive on minimal sleep, it is clearly time to make an extra effort to ensure we get a good prolonged sleep every night.



References:
Extended Wakefulness: Compromised Metabolics in and Degeneration of Locus Ceruleus Neurons (The Journal of Neuroscience -March 19th 2014) 
Lost sleep leads to loss of brain cells, study suggests (BBC World News- Health March 19th 2014)

Friday, March 7, 2014

Reduce all animal proteins in our diet to live longer

It has been well documented that consumption of too much red meat as an adult can lead increased risk for type 2 diabetes, coronary heart disease, stroke and certain cancers.

Now researchers in the US and Italy have gathered enough data, over a period of two decades, to conclude that individuals who have diets high in animal proteins during their middle age are four times more likely to die of cancer then their counterparts who had diets low in animal proteins. A risk some have compared with smoking. An increased risk of developing Diabetes Type 2 was also observed.

Valter Longo, a University of Southern California gerontology professor and director of the school’s Longevity Institute, who co-authored the study pointed out "The great majority of Americans could reduce their protein intake," and added "The best change would be to lower the daily intake of all proteins, but especially animal-derived proteins."

The interesting finding though was the fact that if you started eating more animal proteins after the age of 66 years, it is actually good for your health.


Here are two articles on the subject:

Too much animal-based proteins could lead to early death, study says ( Brady Dennis for The Washington Post)

Tuesday, March 4, 2014

Anger really harmful to cardiovascular health

We all lose our temper from time to time, and it never feels good. An angry outburst is almost always leaves on exhausted, unhappy and feeling drained. We've all been told a bad temper and anger are bad for us at some point in our life.
Now a research study conducted at the Harvard School of Public Health, has found that the risk of a heart attack or stroke is much higher for about two hours immediately following an angry outburst. The risk for a heart attack is increased almost five-folds, whereas the risk is increased two-folds for stroke. This finding is more consistent in individuals with preexisting risk factors.
According to the researchers, 'At a population level, the risk with a single outburst of anger is relatively low - one extra heart attack per 10,000 people per year could be expected among people with low cardiovascular risk who were angry only once a month, increasing to an extra four per 10,000 people with a high cardiovascular risk. But the risk is cumulative, meaning temper-prone individuals will be at higher risk still.'

It is not exactly clear how anger causes the increased risk, but a constant rise in stress level might be significant. Chronic stress is known to lead to high blood pressure which itself is a risk factor for heart diseases. Use of alcohol consumption or smoking for relieving the stress might further exacerbate that risk. Yet, further research is required to fully understand how anger could lead to an increased risk of cardiovascular events and what steps might successfully abate that risk.

This study involved the data analysis of nine studies in which anger and cardiovascular events were self-reported over a period of two decades. It was published in the European Heart Journal on March 3rd, 2014.


P.S: 
References:

 

 

Monday, February 24, 2014

Vitamin E and Selenium supplements may increase risk of cancer

With this increasing obsession with fitness and health the use of supplements such as vitamins, minerals, and herbal has increased exponentially. The increased efforts to stay healthy are good news but the fact that a huge majority of individuals do not even know what supplement to take or not to take, many end up losing any benefit and incur more damage to their health then advantage.

Recent clinical trials have shown that the unnecessary use of certain dietary supplements can lead to far more serious problems then known before. Such a study conducted in the US has shown that the high levels of the mineral Selenium can lead to a 91% increased risk for high grade cancer.
According to the the study leader Dr. Alan Kristal (Fred Hutchinson Cancer Research Centre, Seattle)"These supplements are popular – especially vitamin E – although so far no large, well-designed and well-conducted study has shown any benefits for preventing major chronic disease.
"Men using these supplements should stop, period. Neither selenium nor vitamin E supplementation confers any known benefits, only risks."

This adverse effect appeared only when men with already high levels took the selenium supplement and not in men who originally had low levels. It was also noted that Vitamin E also increased the risk of cancer almost doubling it in men who had low level of selenium.

This study was a follow-up of Select (selenium and vitamin E cancer prevention trial), which originally recruited more than 35,000 men to see if the supplements could help prevent prostate cancer. The main goal of the trial was to prove whether selenium and vitamin E supplements actually prevented prostrate cancer. It was concluded "SELECT was initially planned for a minimum of seven years and a maximum of 12 years of participants taking supplements, plus follow-up observation after the men finished taking their supplements. However, the independent Data and Safety Monitoring Committee (DSMC) for the trial met on September 15, 2008, to review SELECT study data and found that selenium and vitamin E, taken alone or together did not prevent prostate cancer. The committee also determined that it was unlikely selenium and vitamin E supplementation would ever produce a 25 percent reduction in prostate cancer incidence, as the study was designed to show. Based on their recommendation, with SWOG and NCI agreement, SELECT participants were told in October 2008 to stop taking their study supplements." (National Cancer Institute)

The Select trial suggested that Vitamin E intake may have more detrimental effects then initially thought, whereas the outcome of overuse of selenium was still disputed hence the follow up study.     "In 2011, data showed that men taking vitamin E alone had a significantly increased risk of prostate cancer, but men taking vitamin E plus selenium did not.  If men had low selenium levels at the start of the trial, the selenium supplement may have counteracted a negative effect of the vitamin E supplement." (Select study - NCI)

The results of this follow-up study have shown a clear relation between selenium and vitamin E supplements and the increased risk of prostrate cancer.
"In an analysis published in 2014, men who had high levels of selenium at the start of the trial, as assessed by measures of selenium in their toenail clippings, had almost double the chance of developing a high-grade prostate cancer if they took the selenium supplement compared to men with low levels of selenium at the start of the trial.  This finding was unexpected, as previous studies had shown that men with low levels of selenium had an increased risk of prostate cancer that was reduced with supplements (11, 12).  Additionally, men with low levels of selenium at the start of the trial had double the chance of developing a high-grade prostate cancer if they took the vitamin E supplement."
(National Cancer Institute)

A detailed article on the latest results was published on February 21st 2014 in The Guardian, titled
Some vitamin supplements raise risk of cancer in men, research shows.



P.S:
References:
Selenium and Vitamin E Cancer Prevention Trial (SELECT) (National Cancer Institute)
Some vitamin supplements raise risk of cancer in men, research shows. (The Guardian)

Monday, February 17, 2014

Cancer on the rise in the world

Since the release of the  World Cancer Report 2014 by the WHO, we have been seeing headlines like 'Cancer 'tidal wave' on horizon, warns WHO' (BBC World) and for good reason.

The stats in the report have gotten everyone's attention. It suggests that the number of cancer cases might reach 24 million by 2035. It also points out that world health issues such as smoking, drinking, and obesity must be effectively dealt with to reduce that number. 
The International Agency for Research on Cancer (WHO) press release states:

Global battle against cancer won’t be won with treatment alone.
Effective prevention measures urgently needed to prevent cancer crisis.
Based on the latest statistics on trends in cancer incidence and mortality worldwide, this new book reveals how the cancer burden is growing at an alarming pace and emphasizes the need for urgent implementation of efficient prevention strategies to curb the disease.
Despite exciting advances, this Report shows that we cannot treat our way out of the cancer  problem,” states Dr Christopher Wild, Director of IARC and co-editor of the book. “More commitment to prevention and early detection is desperately needed in order to complement improved treatments and address the alarming rise in cancer burden globally.”
In 2012, the worldwide burden of cancer rose to an estimated 14 million newcases per year, a figure
expected to rise to 22 million annually within the next two decades. Over the same period, cancer deaths are predicted to rise from an estimated 8.2 million annually to 13 million per year.
According to the report globally the highest number of diagnosed cancers were lung cancer, breast cancer and cancer of the large bowel. The highest number of cancer deaths were caused by cancer of the lungs, followed by cancers of the liver and stomach.

This World Cancer Report 2014 highlights the presence of a cancer divide.

As a consequence of growing and ageing populations, developing countries are disproportionately affected by the increasing numbers of cancers. More than 60% of the world’s total cases occur in Africa, Asia, and Central and South America, and these regions account for about 70% of the world’s cancer deaths, a situation that is made worse by the lack of early detection and access to treatment.

 Many of the cancers seen in developing countries are high infection related cancers (cancer of liver, cervix and stomach) or are cancer known to be associated with the industrialized lifestyles (cancer of lungs, breast and large bowel). Therefore high mortality from cancer in these countries could be significantly reduced if they have access to effective and affordable cancer treatments but also by implementation of vaccination programs (Hep B and HPV) and preventive efforts towards the spread of tobacco.
The rising number of cancer cases is proving to be detrimental to the economy of even the richest countries. According to the report 'In 2010, the total annual economic cost of cancer was estimated to reach approximately US$ 1.16 trillion. Yet about half of all cancers could be avoided if current knowledge was adequately implemented.'

Last but not least the report stresses on the need for widespread efforts towards early detection and treatment and the promotion of adequate legislation to reduce exposure and risk behaviours.



P.S:
Cancer 'tidal wave' on horizon, warns WHO (BBC World February 4th 2014)
International Agency for Research Cancer  
World Cancer Research Fund International