Showing posts with label Medicine. Show all posts
Showing posts with label Medicine. Show all posts

Tuesday, December 9, 2014

Could light Pollution be another hazardous consequence of urban living?

Living in cities has always been known to increase most individual's stress level. The busy streets, crazy traffic, high noise level and air pollution are some of the things that might be adding to the toll a fast paced city life can take on one's health. Now scientists are adding the super bright nightlights of cities to the list and calling it 'Light Pollution'.
In the article Urban light pollution: why we're all living with permanent 'mini jetlag'(The Guardian) Ellie Violet Bramley writes about studies that have shown that exposure to light after dusk is quite literally unnatural, and may be detrimental to health. Astronomer Dr Jason Pun of the Hong Kong University department of physics has been studying light pollution and has done several studies on the subject. Recently  they set up 18 stations around Hong Kong stretching from commercial urban sector to residential neighborhoods and on to rural areas. When they compared the levels of light to the standard (meaning how bright the sky would be without artificial lights),  they found that the lit areas were about a 1000 times brighter.

Hong Kong Skyline By Barry Chum (Own work) [CC-BY-3.0 (http://creativecommons.org/licenses/by/3.0)], via Wikimedia Commons

According to Dr. Pun, “Similar studies in major capitals like Berlin and Vienna, would find something more of the order of 100 to 200 times brighter.” 

Most cities like Hong Kong, New York, Tokyo and Las Vegas may be proud of their super bright nightscapes and get many visitors who come to see these illuminated cities. But these brightly lit skies may also be causing health problems. Steven Lockley,  a neuroscientist and an associate professor of medicine at Harvard Medical School has been studying the effect of light on alertness, sleep, melatonin levels and its overall impact on human physiology.


Lockley calls any light after dusk as unnatural, he says that with any such exposure "our daytime physiology is triggered and our brains become more alert, our heart rates go up, as does our temperature, and production of the hormone melatonin is suppressed".

The article also mentions Ken Wright at the University of Colorado in Boulder who conducted studies on camping. He found that for campers midnight meant middle of the night, whereas in urban areas the constant presence of light prolongs the daytime, thus leading people living in cities to stay awake longer, sleep later and hence sleep less. This could be causing health problems not yet clearly documented.

Lockley raises a thought-provoking question; "As a society we need to think, do we really need some of these amenities that are putting light pollution into the environment?" adding "Do we need 24/7 garages, do we need 24/7 supermarkets, do we need 24/7 TV? It was only in 1997 that the BBC turned off and there was the national anthem and we all went to bed."

Here are some excerpts of Ellie's article;

The International Dark Sky Association is an organisation of astronomers that aims to teach how to preserve the night sky. Member Scott Kardel says he believes in balance: “While we need certain amounts of light at night for safety, commerce and more, we also need to be more careful about how much light we use, where we use it and for how long.”
But at a more abstract level, Kardel also believes that “having bright skies takes something away from us. All of our ancestors had star-filled skies that inspired countless people in art, literature, religion, science and philosophy.”

It might not be plausible to put the metropolis to bed at dusk, but cities can mitigate some of the worst light pollution. “Proper outdoor lighting,” says Kardel, “conserves energy, reduces glare” and cuts back on so-called light trespass, for example when your neighbour’s bedroom light bleeds into your sitting room.

Lockley thinks LEDS are the “problem, but also the solution: they allow much more sophisticated lighting systems.” The blueness can be fixed, he says. “It is possible to create LED light with multiple colours – you can alter the colours for the right time of day and the right application.” 

“We might not quite be at the point where cities are putting in those types of tuneable street lamps,” he adds. But many communities in the UK have either adopted or trialled “part night lighting”, switching off the lights where they’re not needed or lowering illumination levels for part of the night. Motion-sensing technologies are being tested in the Netherlands and Ireland.

At the centre of this shift is a change in the attitudes of city residents and their governments. In Hong Kong, until only a few years ago the government avoided even using the term “light pollution”, says Pun. “They wouldn’t even admit such a thing exists. If you call it something else, like ‘light nuisance’, then I guess it will make life a little easier. Even though it seems like a gloomy situation, no pun intended, I do see a change of mindset.”

In the end the article has some wonderful tips on how to reduce light pollution.

It’s an obvious one, but switch off any lights you are not using.
Ensure indoor and outdoor lighting is directed at what you’re trying to light and that it’s shaded. Table and floor lamps are better for this than overhead lights.
Use low-watt lightbulbs – you’ll save on bills and reduce glare.
Install dimmer switches so you can alter brightness to suit ambient light.
Use motion sensors or timers so outdoor lights are only on when they need to be.
Install thick curtains or blinds to minimise light escaping your home at night.
Ask your local councillor to get street lamps fitted with directional, low energy lights – after all, residential areas don’t need to be lit up like football pitches 24 hours a day.


References:
 Urban light pollution: why we're all living with permanent 'mini jetlag' (The Guardian- Oct 23rd 2014)
 

Music and your health.

"If music be the food of love, play on" 
                                                           
                                 (William Shakespeare)


When we read that we are bound to agree. Music has been an integral part of most civilizations and still is. Mankind has used music in so many ways; to entertain, to express emotions and get feelings across, to heal and recover, to relax and meditate, and to learn or record facts and history to name a few.

Music is like the soundtrack of our lives. How often we hear a song and can right away be transported to another time, another place where we heard it first or where it impacted us. How often has music brightened up our mood or helped us relax. How many times has music brought so many together, that is why it is the universal language. It is clear that we need music in our lives,  “Without music, life would be a mistake.” as Friedrich Nietzsche concluded.


Over the decades, countless studies and continued research work has repeatedly supported the belief that music can be more than just food for the soul, it can have real beneficial effects on our overall health and well-being. Here are some of those benefits:

Physical benefits

Pain:
According to a study published in Frontiers of Psychology, scientists found that listening to music that is relaxing, highly pleasant, familiar, and self-chosen, reduced pain and increase functional mobility in fibromyalgia patients.

Endurance:
British researchers studied 12 healthy male college students riding stationary bikes while listening to six different songs of their choosing, each with a different tempo. It was observed that not only their pedaling speed changed along with the tempo of the music so did their overall affect. As tempo slowed, they slowed the pedaling, their heart rate decreased, breathing slowed and mileage fell. But as music tempo increased so did their pedaling speed, heart rate, distance covered and showed reduced exertion. Hence the conclusion 'healthy individuals performing submaximal exercise not only worked harder with faster music but also chose to do so and enjoyed the music more when it was played at a faster tempo."
In another study, researchers had 20 moderately active adults (22±4 y), unfamiliar with interval exercise, complete an acute session of SIT(Sprint Interval training) under two different conditions: music and no music. Leading to the conclusion ' Music enhanced in-task performance and enjoyment of an acute bout of SIT.'

Post-exercise recovery:
After a workout music not only helps relax, it also helps the body recover faster. A study published in the Journal of Strength & Conditioning Research showed beneficial effect of both music and rhythm was greater toward the end of the recovery period. Results suggest that listening to music during non structured recovery can be used by professional athletes to enhance recovery from intense exercise.


Sleep:
A study showed classical music to improve the quality of sleep in individuals with poor sleep. Relaxing classical music can thus be used to help alleviate insomnia instead of sleep inducing medications.


Eating Habits:
A recent study found that with softening of the music and lighting while eating, diners end up eating less and enjoying the food more, suggesting that a more relaxed environment increases satisfaction and decreases consumption.

Blood Flow:
Previous studies have demonstrated that music may influence physiologic parameters such as heart rate and blood pressure. A study of the effect of music on endothelial function showed an increased blood flow and a happier mood.


Mental Benefits

Stress:
Over the past years, music has been increasingly used as a therapeutic tool in the treatment of different diseases in healthy and ill subjects over recent years (e.g., the so called "Mozart effect"). Music has been found to lead to release of biochemical measurable stress-reducing effects in some individuals. Some kinds of music have also been known to cause changes in cardiac and neurological functions.
It has also been seen that music helps individuals perform better under pressure if listening to music. Such a study involving basketball players known to choke under pressure, showed improved performance by the same players when listening to upbeat music and lyrics.


Meditation:
Music has been found to cause actual change in brainwave. Researchers found that most music combines many different frequencies that cause a complex set of reactions in the brain, but researchers say specific pieces of music could enhance concentration or promote relaxation.

Mood:
A study found arousal and mood regulation to be the most important dimension of music listening closely followed by self-awareness.

Cognitive function:
Research has shown that upbeat music improves the efficiency and accuracy in performance of workers on assembly lines or quality-control operators. It helps them to stay focused on their work even though what they’re doing is not necessarily interesting, and attention would normally fade over time.

Anxiety:
When used in conjunction with conventional cancer treatments, music therapy has been found to help patients promote a better quality of life; better communicate their fear, sadness, or other feelings; and better manage stress, while alleviating physical pain and discomfort.

Patients:
There is sufficient practical evidence that listening to music while resting in bed after open heart surgery can reduce patients' stress level. Therefore it is recommended that music intervention be offered as an integral part of the multimodal regime offered to patients after cardiovascular surgery. It is a supportive source that increases relaxation. Music is also effective in under conditions and music can be utilized as an effective intervention for patients with depressive symptoms, geriatrics and in pain, intensive care or palliative medicine. However,  music used should be carefully selected incorporating a patient's own preferences to offer an effective method to reduce anxiety and to improve quality of life. The most benefit on health is seen in classic music, meditation music whereas heavy metal music or technosounds are even ineffective or dangerous and will lead to stress and/or life threatening arrhythmias.


References:
5 Science-Backed Reasons Why Music is Good for You (Health- Nov 11, 2014)
20 surprising, science-backed health benefits of music (USA Today- Dec 17, 2013)

Effects of music tempo upon submaximal cycling performance. (Scandinavian Journal of Medicine and Science in Sports- Aug 2010)
Music Enhances Performance and Perceived Enjoyment of Sprint Interval Exercise. (Medicine and Science in Sports and Exercise- Sep 8, 2014)
Effect of Rhythm on the Recovery From Intense Exercise (Journal of Strength and Conditioning Research- April 2013) 
Music improves sleep quality in students. (Journal of Advanced Nursing- May 2008)
Fast Food Restaurant Lighting and Music can reduce Calorie intake and increase Satisfaction
(Psychological Reports- Aug 2012) 
Positive Emotions and the Endothelium: Does Joyful Music Improve Vascular Health? (Circulation- 2008)
From music-beat to heart-beat: a journey in the complex interactions between music, brain and heart. (European Journal of Internal Medicine-Aug 2011)
Alleviating Choking: The Sounds of Distraction (Journal of Applied Sport Psychology- April 2009)
Symposium looks at therapeutic benefits of musical rhythm
 (Stanford News Service- May 2013)
The psychological functions of music listening (Frontiers in Psychology- May 24, 2013)
Music therapy in a comprehensive cancer center. (Journal of the Society of Integrative Oncology- Spring 2008)
Music and health--what kind of music is helpful for whom? What music not? (Published in a German Medical Journal- Dec 2009)













Tuesday, June 24, 2014

Teenage cannabis use and schizophrenia

With the growing wave of legalizing marijuana use across the US, it is important to fully understand the possible consequences of expected increase in it's unrestricted use, specially amongst the youth. A group of scientist at the Feinberg School of Medicine and Northwestern Memorial Hospital have conducted a study which has found a link between teenage Marijuana (Cannabis) use and schizophrenia. This study was published by Schizophrenia Bulletin

The brains of teenagers smoking cannabis daily for about three years showed significant structural changes affecting memory. Some of those changes appear very similar to those seen in the brains of schizophrenics.These youngsters also performed badly when tested on memory tasks, indicating poor memory functioning.


As reported by Marla Paul for Northwestern University on Futurity;

This is the first study to target key brain regions in the deep sub-cortical gray matter of chronic marijuana users with structural MRI and to correlate abnormalities in these regions with an impaired working memory.
Working memory is the ability to remember and process information in the moment and—if needed—transfer it to long-term memory. Previous studies have evaluated the effects of marijuana on the cortex, and few have directly compared chronic marijuana use in otherwise healthy individuals and individuals with schizophrenia.

According to the lead study author Mathew Smith an assistant research professor in psychiatry and behavioral sciences at Northwestern University Feinberg School of Medicine; 

“The study links the chronic use of marijuana to these concerning brain abnormalities that appear to last for at least a few years after people stop using it. With the movement to decriminalize marijuana, we need more research to understand its effect on the brain.”

 But in contrast to these findings another study conducted at the Institute of Psychiatry at King's College London, has shown a genetic link between cannabis use and schizophrenia. Kate Kelland  reports for Reuters that;

The results chime with previous studies linking schizophrenia and cannabis, but suggest the association may be due to common genes and might not be a causal relationship where cannabis use leads to increased schizophrenia risk. 

 "We know that cannabis increases the risk of schizophrenia. Our study certainly does not rule this out, but it suggests that there is likely to be an association in the other direction as well – that a pre-disposition to schizophrenia also increases your likelihood of cannabis use," said Robert Power, who led the study at the Institute of Psychiatry at King's College London.

But what become evident from both these recent studies is the clear connection between adolescent use of cannabis and the development of schizophrenia. Therefore it is important for parents to discourage their children from getting swept up in this growing wave of legal recreational use of marijuana. We need to educate ourselves and our children on the very real dangers and consequences of indiscriminate use of marijuana.
 



References:
Study finds genetic links between schizophrenia and cannabis use (Reuters-June 24, 2014)
Cannabis-Related Working Memory Deficits and Associated Subcortical Morphological Differences in Healthy Individuals and Schizophrenia Subjects  (Schizophrenia Bulletin-December 15, 2013)
Genetic predisposition to schizophrenia associated with increased use of cannabis (Molecular Psychiatry-June 24, 2014)



Sunday, June 22, 2014

Another reason why sitting in front of computer screens for hours on is not a good idea


Wednesday, May 21, 2014

Air Pollution damaging not children's health but also their IQs

In a recent study at Columbia University School of Public Health, researchers have shown that air pollution might affect children's earning potential later in life. The study has been published in The Journal of Public Health Policy May issue.
The researchers gathered data by tracking poor and pregnant African American and Dominican mothers and their children til the age of five.
The results as also discussed by Sydney Brownstone in Fast Company Coexist section showed an inverse relationship in air quality (presence of neurotoxicants, such as polycyclic aromatic hydrocarbons (PAH) released to ambient air by combustion of fossil fuel and other organic material) and the children's IQ. Here are excerpts of the article;

Some of the biggest barriers blocking children's access to opportunity are also the most invisible. It’s no small difference either. If New York City were to reduce its pollution from sources like diesel fumes by even a quarter, affected children could earn an additional $215 million in their lifetimes.
It’s old news that some types of air pollution affect some groups more than others. Poor communities of color are most at risk, often housed in the polluted miasma next to highways, city dumps, landfills, power plants, and other undesirable places to live. New York City is no exception. In 2006, NYU researchers analyzed backpacks of South Bronx schoolchildren to link the borough’s heavy diesel-powered truck traffic to shockingly high rates of childhood asthma hospitalizations.

The Columbia researchers were able to see if pollution exposure correlated with academic performance and IQ. When they factored in the well-documented relationship between IQ and future earnings, the researchers calculated that if the city decreased PAH pollution by a quarter, each child could earn an additional $3,382 on average. Multiply that by the 63,500 kids exposed to this kind of pollution in the city, and the total comes to $215 million in lost dollars.

These findings have been supported by others studies and medical papers. Such as the 2012 paper published by the National Institute of Health in which Harvard Medical School Neurologist Dr. David C. Bellinger concluded that; 

Any effort to compare the neurodevelopmental burden associated with different risk factors is limited by the data available and the assumptions required. It was possible to estimate the total loss of FSIQ points in the population of 0- to 5-year-old U.S. children for a variety of risk factors, including three environmental chemicals: methylmercury, organophosphate pesticides, and lead. Despite the limitations of the approach, it appears that when population impact is considered, the contributions of chemicals to FSIQ loss in children are substantial, in some cases exceeding those of other recognized risk factors for neurodevelopmental impairment in children. The primary reason for this is the relative ubiquity of exposure.  

Although American industry will insist on more targeted and exact data to force any significant regulations to further reduce air pollution and other environmental pollutants, it is clear that harm is being done. If we want our children to have a fair chance at success and progress we need to take action now.



References:
The Toxins That Threaten Our Brains(The Atlantic-May 18, 2014)
(Fast Company-CoExist May 12, 2014)
Air Pollution and Health Risk (EPA)
A Strategy for Comparing the Contributions of Environmental Chemicals and Other Risk Factors to Neurodevelopment of Children  (NIH April 1, 2012)
A Study Links Trucks’ Exhaust to Bronx Schoolchildren’s Asthma  (The New York Times- June 2, 2006)


 

Thursday, May 8, 2014

The autism vs vaccines controversy

In 1998 an article published in the British Journal The Lancet claimed it found a causal connection between the MMR vaccine and autism. Although that article was widely disputed and later retracted, it has left behind a significant following, leading many parents to refuse MMR vaccination for their children. The anti-vaccine groups also stressed on the use of mercury-based preservative Thimerosal in vaccines as a suspected culprit. As a result the government has gradually removed it or reduced it to trace amounts in all vaccines in 2001, in spite of no scientific proof of its possible link to incidence of autism. As explained on the CDC website;

"Over the years, some people have had concerns that autism might be linked to the vaccines children receive. One vaccine ingredient that has been studied specifically is thimerosal, previously used as a preservative in many recommended childhood vaccines. However, in 2001 thimerosal was removed or reduced to trace amounts in all childhood vaccines except for one type of influenza vaccine, and thimerosal-free alternatives are available for influenza vaccine. Evidence from several studies examining trends in vaccine use and changes in autism frequency does not support such an association between thimerosal and autism. Furthermore, a scientific review by the Institute of Medicine (IOM) concluded that "the evidence favors rejection of a causal relationship between thimerosal–containing vaccines and autism." CDC supports the IOM conclusion that there is no relationship between vaccines containing thimerosal and autism rates in children.
The IOM also recently conducted a thorough review of the current medical and scientific evidence on vaccines and certain health events that may be observed after vaccination. It released a report in August 2011 on 8 vaccines given to children and adults that found the vaccines to be generally safe and serious adverse events following these vaccinations to be rare."

The 2012 National Immunization Survey  found that about 90% of children aged 19 to 35 months completed recommended vaccinations and less than 1% received no vaccines at all. But it also highlighted the fact that rates are varied by states and regions therefore leaving some areas vulnerable to outbreaks of measles and other vaccine preventable diseases. The resurgence of measles and whooping cough (Pertussis) in recent years after decades of almost complete extinction could possibly be the distressing consequence of an increasing number of parents refusing the MMR vaccine on grounds of its possible association to autism. 

As explained by Puneet Kollipara in The Washington Post article How the anti-vaccine movement is endangering lives (May 5, 2014).

A measles outbreak that struck a Texas megachurch community late last summer sickened 21 people. And just recently, at least 16 people got sick during a measles outbreak in Ohio. In fact, the Centers for Disease Control and Prevention recently reported 13 measles outbreaks so far in 2014 -- the most since 1996.

According to an article in JAMA News;

Overall, among 140 US residents who acquired measles, 117 (84%) were unvaccinated, and 11 (8%) had unknown vaccination status. Of those who were unvaccinated, 92 (79%) had philosophical objections to vaccination, and 15 cases (13%) occurred among infants younger than 12 months who were not eligible for vaccination.


Besides leading to prevention and saving lives, these vaccines are also economically beneficial, as pointed out by Kuneet Kollipara;

A new study from CDC researchers led by Anne Schuchat analyzed what happened to disease rates as childhood vaccination rates increased starting in the early 1990s. The researchers used these findings to model the resulting effect over the kids' lifetimes. In the analysis, the researchers factored in most routine vaccines recommended for children below age 6 (among them the MMR and whooping cough vaccines). Their findings: Routine childhood vaccinations given between 1994 and 2013 will save 732,000 lives and prevent 322 million cases of illness and 21 million hospitalizations over the course of the children's lifetimes. 

In 2009 alone, the researchers determined, each $1 spent on vaccines and their administration yielded $10 in benefits to society. And the vaccinations from 1994-2013, the researchers found, will save society a net $1.38 trillion, both directly (by reducing health expenses) and indirectly (via the economic activity that is saved from avoided illnesses). That's almost 10 percent of the U.S. economy's gross domestic product.

In the end vaccines may not be without fault but there is no clear cut evidence to their causal link to autism. And they are definitely effective and save lives if given to a significant percentage of the population.



References:
How the anti-vaccine movement is endangering lives (The Washington Post-May 5, 2014).





Saturday, May 3, 2014

The serious and difficult outcomes of saving extremely premature babies.

According to the CDC 1 in every 8 babies born in the US is preterm (birth of an infant prior to 37 weeks of pregnancy). 35% of all infant deaths in 2009 were because of preterm related causes of death. The US health care system spent about $26 billion on preterm births in 2005.
But the statistic that should be raising concern is that 'preterm birth is also a leading cause of long-term neurological disabilities in children.'

With modern medicine and all our advances in medical sciences, we have made it possible to save babies born at 22-23 weeks of gestation.  But preterm births are associated with some serious short term and long term complications. Not only do these prevent the child from living a normal healthy life they can take a severe toll on the family and the community. 

In the article 'Nathan was born at 23 weeks. If I'd known then what I do now, I'd have wanted him to die in my arms' reporter Tracy McVeigh covers the story of Alexia Pearce mother of a three years old son who was born prematurely at 23 weeks and now lives a difficult life with cerebral palsy and chronic lung disease. Alexia loves her son deeply yet she asks if "we are always right to save premature babies". Here are excerpt of the story;

Alexia Pearce looks at her three-year-old son Nathan every day and feels the same rush of guilt. Guilt that she chose to let him live when he was born too early, just 23 weeks into her pregnancy. "If I'd known then what I know now about what extremely premature babies have to go though, I would not have chosen that for my little boy.
"I would have wanted them to give him to me and for him to pass away in my arms. I find the whole issue of what he has been put through, what he continues to be put through, very difficult. I feel very guilty that I took that decision, postponing the inevitable."
"He can't walk or talk. He's oxygen dependent, although hopefully that might change. He has chronic lung disease, cerebral palsy and global developmental delay. He has diabetes inspidus and his thermostat is a bit wonky so he gets hot and cold."
It is, says Pearce, a great taboo to wonder if she should have let her son go when he was born so fragile and weak, but one that she feels strongly that she should break. "More people need to be aware of what these little chaps go through," she said.
"I have no regrets that what has happened has happened. Now this most gorgeous little thing is here and I absolutely adore him. I am so glad I have got to know him. But that doesn't stop me knowing that all I have done is postpone the inevitable. He's not expected to live a very long life. I don't think he'll make it to his teens. He's so frail.

While the latest figures show that 39% of babies born at 24 weeks are now surviving with help from medical advances, the chances of those children suffering no serious ill-effects in later life are low – around six in 100.Last year, researchers from University College Hospital, London, found that premature babies were more sensitive to pain. All pre-term babies are more at risk of a lower IQ, poorer cognitive functioning, learning disabilities and behavioural problems such as attention deficit disorder than full-term babies.
Last year, researchers from University College Hospital, London, found that premature babies were more sensitive to pain. All pre-term babies are more at risk of a lower IQ, poorer cognitive functioning, learning disabilities and behavioural problems such as attention deficit disorder than full-term babies.
"You hear about 'miracle babies' or 'little fighters' and people have such a romantic view about premature babies – 'Oh, there's an incubator for a little while and then they go home and everything is rosy'. It's not."

"Obviously every life deserves a chance, every life. But you wouldn't put an adult through that. You wouldn't put an animal through it. If an adult required that level of medical intervention then someone would be taking the family aside and suggesting gently that the machines are switched off."
Pearce had no warning of her own premature birth, brought about by a sudden complication in the pregnancy, a placental abruption, and had none of the risk factors – she doesn't drink or smoke, isn't obese and her first son, Dominick, now five, was born at full term.

"Birth and death are the most natural processes a body can go through and Nathan's birth and treatment was so far removed from that. Strange birth, choices to be made, difficult bonding. I had to wait six weeks to hold my son and when I did he was still attached to a ventilator and I had many nurses around me. It was all so clinical."
An advocate or counsellor figure would, she feels, help the mother think more clearly about the situation.

But for Alexia Pearce, it's important for families to fully understand too that the difficult times do not end when the baby leaves the incubator. "When you go into labour that early, nobody is a winner," she said. "I'm not saying stop people from having their premature baby resuscitated. I'm not saying babies shouldn't be saved. I am saying that the myth that there is a happy ever after needs to be explored and it's important that we talk about it.

(Read Complete Article)

References:
'Nathan was born at 23 weeks. If I'd known then what I do now, I'd have wanted him to die in my arms' (The Guardian/The Observer)
CDC Reproductive Health- Preterm Births 
Preterm Births- Complications (Mayo Clinic) 
(NCBI- National Center for Biotechnology Information)





Wednesday, April 30, 2014

A surge in antimicrobial resistance reported by WHO

The constant increase in the incidence of antimicrobial resistant infections is now becoming a major concern for the WHO. According to their recent report on 'Antimicrobial Resistance' this is a very real threat to global public health.
In recent decades the world has been aware of the rise in antibiotic resistant bacteria and has been trying to promote responsible use of antibiotic treatment in an effort to counteract this rise. But it is the first time that the WHO has warned of a much more serious problem since antimicrobial resistance covers a much broader spectrum of microbes (eg. parasites, fungi, and viruses).

If such a resistance is seen the world over, effective treatment of even common infection may be difficult or impossible. According to the report;

Infections caused by resistant microorganisms often fail to respond to the standard treatment, resulting in prolonged illness, higher health care expenditures, and a greater risk of death.
As an example, the death rate for patients with serious infections caused by common bacteria treated in hospitals can be about twice that of patients with infections caused by the same non-resistant bacteria. For example, people with MRSA (methicillin-resistant Staphylococcus aureus, another common source of severe infections in the community and in hospitals) are estimated to be 64% more likely to die than people with a non-resistant form of the infection.


Although this kind of resistance to antimicrobial is being seen more around the world. Unfortunately not only do many of these cases go unreported, but often the infections last longer, leaving the patients infectious for a much longer time period , thus increasing the risk of further spreading the infection to others.

The report also highlights another consequence of AMR (Antimicrobial resistance), when infections fail to respond to first line of drugs, doctors have to resort to more aggressive therapies which are far more expensive, patients need medical supervision for a longer duration and hospital stays are also prolonged. All together these factors significantly increase the health care costs.

According to the report, the economic outcome can be damaging;

The growth of global trade and travel allows resistant microorganisms to be spread rapidly to distant countries and continents through humans and food. Estimates show that AMR may give rise to losses in Gross Domestic Product of more than 1% and that the indirect costs affecting society may be more than 3 times the direct health care expenditures. It affects developing economies proportionally more than developed ones. 

Some of the noteworthy resistances being seen globally are:

Resistance in Bacteria

WHO’s 2014 report on global surveillance of antimicrobial resistance reveals that antibiotic resistance is no longer a prediction for the future; it is happening right now, across the world, and is putting at risk the ability to treat common infections in the community and hospitals. Without urgent, coordinated action, the world is heading towards a post-antibiotic era, in which common infections and minor injuries, which have been treatable for decades, can once again kill.

Resistance in Tuberculosis

Globally, 6% of new TB cases and 20% of previously treated TB cases are estimated to have MDR-TB, with substantial differences in the frequency of MDR-TB among countries. Extensively drug-resistant TB (XDR-TB, defined as MDR-TB plus resistance to any fluoroquinolone and any second-line injectable drug) has been identified in 92 countries, in all regions of the world.

Resistance in Malaria

The emergence of P. falciparum resistance to artemisinin in the Greater Mekong subregion is an urgent public health concern that is threatening the ongoing global effort to reduce the burden of malaria. Routine monitoring of therapeutic efficacy is essential to guide and adjust treatment policies. It can also help to detect early changes in P. falciparum sensitivity to antimalarial drugs.

Resistance in HIV

At the end of 2011, more than 8 million people were receiving antiretroviral therapy in low- and middle-income countries to treat HIV. Although it can be minimized through good programme practices, some amount of resistance to the medications used to treat HIV is expected to emerge. 

There is no clear evidence of increasing levels of resistance to other classes of HIV drugs. Of 72 surveys of transmitted HIV drug resistance conducted between 2004 and 2010, 20 (28%) were classified as having moderate (between 5% and 15%) prevalence of resistance.


Resistance in Influenza

Several countries have developed national guidance on their use and have stockpiled the drugs for pandemic preparedness. The constantly evolving nature of influenza means that resistance to antiviral drugs is continuously emerging.
By 2012, virtually all influenza A viruses circulating in humans were resistant to drugs frequently used for the prevention of influenza (amantadine and rimantadine). However, the frequency of resistance to the neuraminidase inhibitor oseltamivir remains low (1-2%). Antiviral susceptibility is constantly monitored through the WHO Global Surveillance and Response System.


How can this surge be slowed down?

According to the WHO report, this rise in AMR is the result of a multiple factors. 
Here are some suggestions it provides in the report:

People
  • using antibiotics only when they are prescribed by a certified health professional;
  • completing the full treatment course, even if they feel better;
  • never sharing antibiotics with others or using leftover prescriptions.
Health Care Workers And Pharmacists
  • enhancing infection prevention and control;
  • prescribing and dispensing antibiotics only when they are truly needed;
  • prescribing and dispensing the right antibiotic(s) to treat the illness.
Policymakers 
  • strengthening resistance tracking and laboratory capacity;
  • strengthening infection control and prevention;
  • regulating and promoting appropriate use of medicines;
  • promoting cooperation and information sharing among all stakeholders.
Policymakers, Scientists and Industry
  • fostering innovation and research and development of new vaccines, diagnostics, infection treatment options and other tools. 

In the end what is the WHO doing to counteract AMR? 
 
In 2014, WHO published its first global report on surveillance of antimicrobial resistance, with data provided by 114 countries.
WHO is guiding the response to AMR by:
  • bringing all stakeholders together to agree on and work towards a coordinated response;
  • strengthening national stewardship and plans to tackle AMR;
  • generating policy guidance and providing technical support for Member States;
  • actively encouraging innovation, research and development.
 

















References:
WHO Report on Antimicrobial Resistance (Updated April 2014)
Detect and Protect Against Antibiotic Resistance Budget Initiative (CDC)

Sunday, April 20, 2014

The damage caused by bullying persists much longer then the bullying itself

According to a longitudinal British study just published in the American Journal of Psychiatry, the detrimental effects of bullying can lasts for decades and influence a person's socioeconomic status, social relationships, often leading to a poorer quality of life as far out as in their 50s.
As reported by the researchers of the study;

The impact of bullying victimization was not limited to indicators of adult health. Children who  were frequently bullied had lower educational levels at midlife, and men in the labor market were  more likely to be unemployed and to earn less than their peers. Social relationships in adulthood were affected too; children who were bullied were at increased risk of living without a spouse or partner at age 50, were less likely to have met up with friends in the recent past, and were less  likely to have access to social support if they were sick. Bullying victimization also affected adult well-being; being bullied was associated with lower perceived quality of  life at age 50 and lower satisfaction with life so far. Cohort members who had been frequently bullied also anticipated less life satisfaction in the years to come. When  controlling for childhood confounders, bullying victimization became marginally associated with unemployment (for men), net pay (for men), and meeting friends in the  last 2 weeks. All other associations remained significant.
 
In this study data was collected from almost 98% of all births in one week of 1958 in Scotland, England and Wales, leading to about 18,000 participants. Subsequent follow-up were then carried out at age 7, 11 and 16 years in their childhood, and then at ages 23, 33, 42, and 50 years in adulthood. To assess presence and frequency of bullying during childhood researchers interviewed parents. Whereas the psychological distress resulting in adult life was assessed through various standardized test.

It is clear from these observations that in addition to effectively reducing incidents of childhood bullying efforts must be made to minimize its effect on mental, emotional and physical.

To learn more about bullying and to find help please check Stopbullying.gov


References:
Adult Health Outcomes of Childhood Bullying Victimization: Evidence From a Five-Decade Longitudinal British Birth Cohort (American Journal of Psychiatry)
Mental And Physical Toll Of Bullying Persists For Decades (Health News from NPR)
 

Friday, April 18, 2014

Older dads might increase the risk of mental health issues in their children

A child's health issues have often been linked to their mother's age at time of their birth. Now a study at University of Indiana has found evidence that a father's age can influence a child's risk of developing conditions such as autism, ADHD and bipolar disorder. The children of older fathers were also seen to be more likely to consider suicide.

As reported in The Independent by Ian Johnston in his article Children of older dads face more health problem;
Scientists at Indiana University found that a child born when their father is 45 was 3.5 times more likely to have autism, 13 times more likely to have ADHD and 25 times more likely to have bipolar disorder than the child of a 24-year-old man.
Suicidal behaviour and substance misuse was twice as likely, according to the study, which is published today in the journal JAMA Psychiatry.
Brian D’Onofrio, who led the research, told The Times: “We were shocked by the findings. The specific associations with paternal age were much, much larger than in previous studies.”
The researchers looked at information about everyone born in Sweden from 1973 until 2001, some 2,615,081 people.
Christopher Barratt, a professor of Reproductive Medicine at Dundee University, suggested younger men should consider freezing their sperm in case they want to have a child when they are in their 40s.

(Read on)


References:
Children of older dads face more health problems (The Independent- April 4, 2014) 

 


Friday, April 4, 2014

No such thing as right-brained or left-brained

Remember all those quizzes meant to figure out whether you are left-brained or right-brained? Well, researchers have just declared them all useless since there is no such thing as left-brained or right-brained.
Although distinct skills have been attributed to whichever hemisphere is dominant for ages and seemed to make sense but sadly they have no scientific basis according to a two year research completed by neuroscientists at University of Utah. The study published in the Plos One Journal is based on a two years long study involving scanning the brains of more then a 1000 individuals between the ages of 7-29 while performing such simple tasks such as lying quietly or reading. These scans were used to measure these individuals' brain functional lateralization meaning the specific mental functions occurring on each side of the brain. For accuracy functional lateralization was measured for each pair of 7266 regions of the grey matter.
Analysis of the data collected as a result lead to the conclusion
" An individual brain is not “left-brained” or “right-brained” as a global property, but that asymmetric lateralization is a property of individual nodes or local subnetworks, and that different aspects of the left-dominant network and right-dominant network may show relatively greater or lesser lateralization within an individual. If a connection involving one of the left hubs is strongly left-lateralized in an individual, then other connections in the left-dominant network also involving this hub may also be more strongly left lateralized, but this did not translate to a significantly generalized lateralization of the left-dominant network or right-dominant network. Similarly, if a left-dominant network connection was strongly left lateralized, this had no significant effect on the degree of lateralization within connections in the right-dominant network, except for those connections where a left-lateralized connection included a hub that was overlapping or close to a homotopic right-lateralized hub."

(Read Complete Article)








References:


Friday, March 7, 2014

Reduce all animal proteins in our diet to live longer

It has been well documented that consumption of too much red meat as an adult can lead increased risk for type 2 diabetes, coronary heart disease, stroke and certain cancers.

Now researchers in the US and Italy have gathered enough data, over a period of two decades, to conclude that individuals who have diets high in animal proteins during their middle age are four times more likely to die of cancer then their counterparts who had diets low in animal proteins. A risk some have compared with smoking. An increased risk of developing Diabetes Type 2 was also observed.

Valter Longo, a University of Southern California gerontology professor and director of the school’s Longevity Institute, who co-authored the study pointed out "The great majority of Americans could reduce their protein intake," and added "The best change would be to lower the daily intake of all proteins, but especially animal-derived proteins."

The interesting finding though was the fact that if you started eating more animal proteins after the age of 66 years, it is actually good for your health.


Here are two articles on the subject:

Too much animal-based proteins could lead to early death, study says ( Brady Dennis for The Washington Post)

Tuesday, March 4, 2014

Anger really harmful to cardiovascular health

We all lose our temper from time to time, and it never feels good. An angry outburst is almost always leaves on exhausted, unhappy and feeling drained. We've all been told a bad temper and anger are bad for us at some point in our life.
Now a research study conducted at the Harvard School of Public Health, has found that the risk of a heart attack or stroke is much higher for about two hours immediately following an angry outburst. The risk for a heart attack is increased almost five-folds, whereas the risk is increased two-folds for stroke. This finding is more consistent in individuals with preexisting risk factors.
According to the researchers, 'At a population level, the risk with a single outburst of anger is relatively low - one extra heart attack per 10,000 people per year could be expected among people with low cardiovascular risk who were angry only once a month, increasing to an extra four per 10,000 people with a high cardiovascular risk. But the risk is cumulative, meaning temper-prone individuals will be at higher risk still.'

It is not exactly clear how anger causes the increased risk, but a constant rise in stress level might be significant. Chronic stress is known to lead to high blood pressure which itself is a risk factor for heart diseases. Use of alcohol consumption or smoking for relieving the stress might further exacerbate that risk. Yet, further research is required to fully understand how anger could lead to an increased risk of cardiovascular events and what steps might successfully abate that risk.

This study involved the data analysis of nine studies in which anger and cardiovascular events were self-reported over a period of two decades. It was published in the European Heart Journal on March 3rd, 2014.


P.S: 
References:

 

 

Monday, February 24, 2014

Vitamin E and Selenium supplements may increase risk of cancer

With this increasing obsession with fitness and health the use of supplements such as vitamins, minerals, and herbal has increased exponentially. The increased efforts to stay healthy are good news but the fact that a huge majority of individuals do not even know what supplement to take or not to take, many end up losing any benefit and incur more damage to their health then advantage.

Recent clinical trials have shown that the unnecessary use of certain dietary supplements can lead to far more serious problems then known before. Such a study conducted in the US has shown that the high levels of the mineral Selenium can lead to a 91% increased risk for high grade cancer.
According to the the study leader Dr. Alan Kristal (Fred Hutchinson Cancer Research Centre, Seattle)"These supplements are popular – especially vitamin E – although so far no large, well-designed and well-conducted study has shown any benefits for preventing major chronic disease.
"Men using these supplements should stop, period. Neither selenium nor vitamin E supplementation confers any known benefits, only risks."

This adverse effect appeared only when men with already high levels took the selenium supplement and not in men who originally had low levels. It was also noted that Vitamin E also increased the risk of cancer almost doubling it in men who had low level of selenium.

This study was a follow-up of Select (selenium and vitamin E cancer prevention trial), which originally recruited more than 35,000 men to see if the supplements could help prevent prostate cancer. The main goal of the trial was to prove whether selenium and vitamin E supplements actually prevented prostrate cancer. It was concluded "SELECT was initially planned for a minimum of seven years and a maximum of 12 years of participants taking supplements, plus follow-up observation after the men finished taking their supplements. However, the independent Data and Safety Monitoring Committee (DSMC) for the trial met on September 15, 2008, to review SELECT study data and found that selenium and vitamin E, taken alone or together did not prevent prostate cancer. The committee also determined that it was unlikely selenium and vitamin E supplementation would ever produce a 25 percent reduction in prostate cancer incidence, as the study was designed to show. Based on their recommendation, with SWOG and NCI agreement, SELECT participants were told in October 2008 to stop taking their study supplements." (National Cancer Institute)

The Select trial suggested that Vitamin E intake may have more detrimental effects then initially thought, whereas the outcome of overuse of selenium was still disputed hence the follow up study.     "In 2011, data showed that men taking vitamin E alone had a significantly increased risk of prostate cancer, but men taking vitamin E plus selenium did not.  If men had low selenium levels at the start of the trial, the selenium supplement may have counteracted a negative effect of the vitamin E supplement." (Select study - NCI)

The results of this follow-up study have shown a clear relation between selenium and vitamin E supplements and the increased risk of prostrate cancer.
"In an analysis published in 2014, men who had high levels of selenium at the start of the trial, as assessed by measures of selenium in their toenail clippings, had almost double the chance of developing a high-grade prostate cancer if they took the selenium supplement compared to men with low levels of selenium at the start of the trial.  This finding was unexpected, as previous studies had shown that men with low levels of selenium had an increased risk of prostate cancer that was reduced with supplements (11, 12).  Additionally, men with low levels of selenium at the start of the trial had double the chance of developing a high-grade prostate cancer if they took the vitamin E supplement."
(National Cancer Institute)

A detailed article on the latest results was published on February 21st 2014 in The Guardian, titled
Some vitamin supplements raise risk of cancer in men, research shows.



P.S:
References:
Selenium and Vitamin E Cancer Prevention Trial (SELECT) (National Cancer Institute)
Some vitamin supplements raise risk of cancer in men, research shows. (The Guardian)

Wednesday, February 12, 2014

A Survey for all parents of teenagers : Monitoring the Future 2013 Survey Results

I am sharing some informational posters on NIDA ( National Institute on Drug Abuse) to help all parents better understand the degree to which our kids are exposed to drugs and how prevalent the use of illicit drugs in youngsters is. Knowledge and information are power, the more we understand the seriousness of this problem, the less likely we will be to support such crazy legislation as the legalization of Marijuana. Please if you come across this post, do share it with your teenagers and middle schoolers.
Description: Monitoring the Future is an annual survey of 8th, 10th, and 12th-graders conducted by researchers at the University of Michigan, Ann Arbor, under a grant from the National Institute on Drug Abuse, part of the National Institutes of Health. Since 1975, the survey has measured drug, alcohol, and cigarette use and related attitudes in 12th-graders nationwide. Eighth and 10th graders were added to the survey in 1991. Overall, 41,675 students from 389 public and private schools participated in the 2013 survey.
Description: Last Two Decades of Alcohol, Cigarette, and Illicit Drug Use*
*Past 30 day use.
This graphic illustrates past 30 day alcohol, cigarette, and illicit drug use among 8th, 10th, and 12th graders from 1993 through 2013. In general, alcohol and cigarette use has decreased, and illicit drug use, which declined in the late 1990s and early 2000s, has been increasing in recent years.
Description: Marijuana: As Perceived Harm Drops, Use Goes Up
* Past-year use in 12th graders.
Three points in time are shown—1993, 2003, 2013— for marijuana use and the perception of risk (saw great risk in smoking marijuana occasionally) among 12th graders.
 Description: 60% of high school seniors do not view regular marijuana use as harmful, which is nearly double from 20 years ago. The potency of marijuana, as measured by THC content, has steadily increased over the last few years, which means that daily use of today’s marijuana may have greater health consequences than use of marijuana from 10 to 20 years ago.
Description: Prescription/Over-the-Counter vs. Illicit Drugs
After marijuana, prescription and over-the-counter medications account for most of the top drugs abused by 12th graders in the past year.


Description: Abuse of Some Synthetic Drugs is Down.
These are substances that are chemically similar to and/or mimic the effects of illicit drugs. This year, 7.9% of high school seniors reported past-year use of K2/Spice (sometimes called synthetic marijuana), down from last year’s number of 11.3%. Past-year use of the substances called “bath salts” was low for all three grades - at or below 1%.

P.S:Monitoring the Future 2013 Survey Results(NIDA)

Friday, January 24, 2014

Easy way to lose weight... just turn the heat down

Obesity and the struggle to lose weight is starting to become the plight of our time. Much research  is being done to find effective ways to understand the causes and finding effective ways to win this losing battle. Right now, more than one third of adults in the US are obese or overweight and a little more then a quarter of the adults in UK is obese or overweight.
Amongst all that research work a recent study published in Trends in Endocrinology & Metabolism Journal, suggests that central heating might be another contributing factor to rising number of overweight individuals. As the temperature in homes, offices, hospitals and most places is being kept high our bodies are no longer burning that many calories to keep the body warm. Normally our metabolism rate (BMR) rise in cold weather to produce body heat. About 80% of the energy produced from our food intake is used up by our BMR.

According to the researchers at Maastricht University, a temperature of 66F would suffice to maintain a normal balance. The report also points out that about 90% of people remain mostly indoors while keeping the temperature at maximum comfort levels in turn minimizing caloric use by our bodies to maintain normal body temperature, shifting the balance towards weight gain.

Although lowering the thermostat alone may not lead to weight loss but it will definitely help along with exercise and diet. The report also mentions a study from  Japan in which volunteers showed a decrease in body fat after spending two hours a day in 17C over a period of six weeks.According to BBC World reporter James Gallagher;

Dr Wouter van Marken Lichtenbelt told the BBC: "19C is enough - and not for the whole day.
"Energy increases were in the order of 6% in mild cold, and in the long term that could really make a difference.
"It could be a substantial influence and help in combination with food changes and exercise." 
He said people could "try turning the thermostat down" at home or "go outside".


P.S: 
Central heating may make you fat, say researchers (BBC World) 
Want to lose weight? Try turning your heating down: Being cold is a 'cheap way to get slim' (Daily Mail UK)





 

Tuesday, January 21, 2014

Shift work clearly detrimental to health

It is a fact that doing the night shift at work is terribly hard. It not only affect our personal and social lives it also throws our whole sleep cycle into chaos. Now scientists at the Sleep Research Center Surrey have found definite proof that night work can lead to long term damage starting at molecular level. Night shift work has been linked to a higher risk of type 2 diabetes, heart attacks and cancer.

According to an article in BBC World News by James Gallagher;
'Experts said the scale, speed and severity of damage caused by being awake at night was a surprise.

The human body has its own natural rhythm or body clock tuned to sleep at night and be active during the day.
It has profound effects on the body, altering everything from hormones and body temperature to athletic ability, mood and brain function.'

Scientists observed 22 individuals as their bodies adjusted from their normal patterns to working the night shift. Preliminary blood test showed that 6% genes had precise daily activity cycles. As the individuals got into a night work routine, these cycles were thrown off. 
The researchers call this 'Chrono-Chaos', here the scientists on the team explain it;

"Over 97% of rhythmic genes become out of sync with mistimed sleep and this really explains why we feel so bad during jet lag, or if we have to work irregular shifts," said Dr Simon Archer, one of the researchers at the University of Surrey.
Fellow researcher Prof Derk-Jan Dijk said every tissue in the body had its own daily rhythm, but with shifts that was lost with the heart running to a different time to the kidneys running to a different time to the brain.
He told the BBC: "It's chrono-chaos. It's like living in a house. There's a clock in every room in the house and in all of those rooms those clocks are now disrupted, which of course leads to chaos in the household."
Prof Dijk added: "We of course know that shift work and jet lag is associated with negative side effects and health consequences.
"They show up after several years of shift work. We believe these changes in rhythmic patterns of gene expression are likely to be related to some of those long-term health consequences."

According to Web MD about 8.6 million people do shift work, meaning either they work the night shift or they rotate shifts during the week.  These include police officers, firefighters, nurses, doctors, pilots, waitresses, truck drivers, and many more professionals. Even a personal trainer who works out at the gym with clients in the early mornings and evenings is a shift worker.
Some of the short term health problems seen more commonly in shift workers are; 
  • Gastrointestinal symptoms like upset stomach, nausea, diarrhea, constipation, and heartburn
  • Increased risk of injuries and accidents
  • Insomnia
  • Decreased quality of life
  • General feeling of being unwell

Whereas the long term effects on health are harder to measure but there has been compelling proof that shift workers might be more prone to these long term medical problems;
  • Cardiovascular disease
  • Diabetes and Metabolic Disorder
  • Depression and Mood Disorders
  • Serious Gastrointestinal Problems
  • Obesity
  • Problems with Fertility and Pregnancy
  • Cancer
 Although most of these long term effects may occur only after decades of disruptive shift work, but some health problems might develop much faster. For many professions shift work is inevitable, hence can not be completely avoided. In those cases, here are some suggestions on the Web MD to help minimize the damage:
  • Eat Well and Exercise
  • Get enough Sleep
  • Change your Schedule
  • See your Doctor

P.S:
References
Night work 'throws body into chaos' (BBC World News)
The Health Risks of Shift Work (Web MD)